· United States edition: online, self-paced courses with certificate

Patient safety and medicines

Sepsis and the Deteriorating Patient

Recognize, escalate and treat sepsis and clinical deterioration under U.S. standards, from the bedside to the board

  • 3hours
  • 10sections
  • 20final questions
  • 80%pass mark
  • PDFcertificate
  • Online and self-paced, on any device
  • Reflective account template
  • Knowledge checks in every section
  • Instant certificate of completion

Reviewed by our expert editorial team · how we check every course

Written for US practiceUpdated 5 October 2026

What you will learn

  • Define sepsis and septic shock using Sepsis-3, and explain how SIRS-based severe sepsis (CMS SEP-1) and the Phoenix pediatric criteria are used in U.S. practice.
  • Describe the U.S. framework for sepsis care: CDC Hospital Sepsis Program Core Elements, CMS SEP-1 in the IQR and Hospital VBP programs, Joint Commission expectations on recognizing and responding to deterioration, 42 CFR 482.42 and state requirements.
  • Recognize early physiological signs of deterioration, including counted respiratory rate, mental status, trends and changes from the patient's own baseline.
  • Compare SIRS, qSOFA, NEWS, MEWS and electronic alerts, and apply the Surviving Sepsis Campaign recommendation against qSOFA as a single screening tool.
  • Identify atypical presentations in older adults, immunocompromised, post-operative, pediatric and pregnant or postpartum patients.
  • Apply SEP-1 time zero and bundle elements and the Surviving Sepsis Campaign 2021 recommendations on antimicrobial timing, fluids, MAP targets, vasopressors and ICU admission.
  • Escalate a possible septic patient using a structured call with a timed request, CUS, the two-challenge rule, the chain of command and the rapid response team, and respond to family concern.
  • Explain New York's sepsis protocol requirements under 10 NYCRR 405.4 and the pediatric Parents' Bill of Rights under 10 NYCRR 405.7.
  • Describe sepsis responsibilities in EMS, emergency, inpatient, nursing facility, outpatient, telehealth, dental and pharmacy settings, including antimicrobial stewardship.
  • Document deterioration, escalation and reassessment accurately, and plan reflection and remediation if your care of a deteriorating patient is questioned.

Who this course is for

U.S. licensed health professionals: physicians and residents, PAs, nurse practitioners and other APRNs, RNs and LPN/LVNs, pharmacists, dentists and dental hygienists, paramedics and allied health professionals.

After a concern

Structured learning and a written reflection to show insight after a complaint, an investigation or a board inquiry.

Routine learning

Focused learning on a core standard of practice, with a certificate and reflection for your portfolio.

About this course

This course teaches U.S. licensees to recognize sepsis and clinical deterioration early, escalate effectively and support time-critical treatment. It covers the definitions in use in U.S. care (Sepsis-3, SIRS-based severe sepsis and the 2024 Phoenix criteria for children), the CDC Hospital Sepsis Program Core Elements, the CMS SEP-1 measure and its place in the Hospital Inpatient Quality Reporting and Value-Based Purchasing programs, The Joint Commission's requirement that hospitals recognize and respond to changes in a patient's condition, the Surviving Sepsis Campaign 2021 guidelines, rapid response systems, and New York's Rory's Regulations and Parents' Bill of Rights.

It is written for physicians and residents, PAs, nurse practitioners and other APRNs, RNs and LPN/LVNs, pharmacists, dentists and dental hygienists, paramedics and other allied health professionals working in emergency departments, inpatient units, ICUs, nursing facilities, urgent care, primary care, telehealth, dental practices and community pharmacies. It is also useful for licensees whose recognition or escalation of a deteriorating patient has been questioned by an employer, a peer review committee or a state board.

Sepsis matters in the United States because it is common, deadly and often recognized late. The CDC reports about 1.7 million adult cases a year, and many patients had recent contact with health care before they were admitted. Hospitals are measured and paid partly on sepsis care, and state boards judge each licensee on whether they assessed, recognized, escalated and documented to the standard of care. This course gives you practical habits, scripts and documentation skills to do that, and to show it.

Course details

Learning time
Approximately 3 hours (estimated learning time including knowledge checks, reflection and assessment)
Standards covered
CDC Hospital Sepsis Program Core Elements; CMS SEP-1 Severe Sepsis and Septic Shock: Management Bundle (CBE #0500, formerly NQF #0500), Hospital IQR and Hospital VBP programs; The Joint Commission hospital requirements on recognizing and responding to changes in a patient's condition; 42 CFR 482.42; Surviving Sepsis Campaign 2021 adult and 2020 pediatric guidelines; Sepsis-3 and Phoenix Sepsis Criteria; New York 10 NYCRR 405.4 (Rory's Regulations) and 405.7 (Parents' Bill of Rights); AHRQ TeamSTEPPS; state practice acts and board standards
Format
Self-paced, gated lessons with knowledge checks, case studies and reflection
Assessment
20 scenario-based questions, 80% to pass (16 of 20)
Outcome
Certificate of completion and a written reflection for your learning record
Alignment
Mapped to CDC, CMS and Joint Commission expectations, Surviving Sepsis Campaign guidance, New York sepsis regulations and the standards of practice applied by state boards; education, not board-approved

Course curriculum

10 sections · 26 lessons · 3 hours · 20-question final assessment

  1. 1Sepsis in the United States: definitions, burden and framework3 lessons
    • What sepsis is, and the language U.S. clinicians use
    • The scale of sepsis in the United States and who is at risk
    • The U.S. framework: CDC, CMS, The Joint Commission, states and boards
  2. 2Recognizing deterioration and sepsis early3 lessons
    • How deterioration looks: the vital signs and the subtle signs
    • Screening tools, early warning scores and electronic alerts
    • High-risk groups and atypical presentations
  3. 3The first hours: bundles, guidelines and evidence4 lessons
    • Time zero and the SEP-1 bundle
    • What the Surviving Sepsis Campaign recommends
    • The evidence on timing, and the risks of getting it wrong in either direction
    • After the first hours: reassessment, de-escalation and recovery
  4. 4Escalation and rapid response3 lessons
    • Rapid response systems: how hospitals are designed to catch deterioration
    • Escalating a septic patient: clear calls, read-back and the chain of command
    • Patients and families who say "something is wrong"
  5. 5Sepsis across settings and professions4 lessons
    • Emergency departments and prehospital care
    • Inpatient units, post-operative care and nursing facilities
    • Outpatient, dental, telehealth and community pharmacy
    • Pharmacists and the antimicrobial pathway
  6. 6Children, pregnancy and New York's Rory's Regulations3 lessons
    • Children: recognizing pediatric sepsis
    • New York's Rory's Regulations and the Parents' Bill of Rights
    • Pregnancy and the postpartum period
  7. 7Documentation, accountability and improvement3 lessons
    • Documenting deterioration and sepsis care
    • When sepsis is missed: boards, claims, disclosure and learning
    • Improving your own practice and your team's
  8. 8Conclusion and key points1 lesson
    • Conclusion and key points
  9. 9References and further reading1 lesson
    • References and further reading
  10. 10Your reflective account1 lesson
    • Your reflective account

Assessment and certificate

Final assessment

20scenario-based questions

  • Pass mark 80%: 16 correct out of 20
  • Knowledge checks in each section as you go
  • Tests whether you can apply the standards, not recall a page
  • Not passed yet? Review the sections and retake it

Certificate of completion

Certificate of completion. Not CE or CME credit unless accepted by your board.

  • Your name, the course title and the hours
  • Completion date and a unique certificate ID that can be verified
  • Ready to download as a PDF as soon as you complete the course
Sample certificate of completion issued to a sample learner
Sample certificate. Yours shows your name, the course, the completion date and a certificate number anyone can verify.

Your reflective account

The course includes a structured reflective account template: guided prompts to record what you learned, how you will apply it and how the change will show in your practice. It gives you written evidence of insight after a concern, and a ready record for your learning portfolio.

Write it in your own words and leave out anything that could identify a patient, a colleague or a case. If you have an open complaint or case, talk to your adviser before reflecting on it in writing.

Questions about this course

Should qSOFA be used on its own to screen for sepsis?

No. The Surviving Sepsis Campaign 2021 guidelines recommend against using qSOFA as a single screening tool compared with SIRS, NEWS or MEWS. The course compares the tools and electronic alerts, and stresses basics that are often missed, such as a properly counted respiratory rate, mental status and trends from the patient's baseline.

What is SEP-1 and why does it matter to individual clinicians?

SEP-1 is the CMS measure for early management of severe sepsis and septic shock, used in hospital quality reporting and value-based purchasing. It defines time zero and bundle elements such as lactate, blood cultures, antibiotics and fluids. The course explains how individual actions and documentation feed into it.

How do I escalate when I think a patient has sepsis and I'm not being heard?

Use a structured call with a clear, timed request, then CUS language and the two-challenge rule if needed, and follow the chain of command or call the rapid response team. The course gives scripts for each step and covers responding when a family member says the patient is not themselves.

Do outpatient and EMS clinicians need sepsis training?

Yes. Many patients have seen a clinician shortly before they are admitted with sepsis. The course covers recognition and referral in EMS, urgent care, primary care, telehealth, nursing facilities, dental practices and community pharmacies, as well as atypical presentations in older, immunocompromised, pediatric and pregnant or postpartum patients.

What is included in the sepsis training?

$89 for about three online hours, self-paced. Checks per section, 20 final questions at 80%, then the certificate and a review of how you spot and escalate sepsis. New York's Rory's Regulations and the pediatric Parents' Bill of Rights are explained, but no state-mandate credit is claimed.

How this course was built

Official sources only

Every legal and regulatory point comes from primary sources: state practice acts and board rules, federal law and national professional codes of ethics. Anything we cannot confirm is left out.

Original, edition by edition

Lessons, scenarios and assessment questions are written by us for each edition separately, then checked for accuracy, teaching quality and fair assessment before publication.

Reviewed when rules change

When a code, standard or law changes, the affected courses are reviewed and updated. Reported errors in legal or regulatory facts are corrected first.

Page updated 5 October 2026

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